Enhancement of Serum Myonectin Levels by Progressive Resistance Training in Rats Fed with High-Fat Diet and Sucrose Solution

Background: Myonectin (CTRP15) is a newly discovered myokine with important metabolic functions. It was shown that circulating myonectin levels decreased in obesity. Objectives: The present study investigated the effect of 8 weeks progressive resistance training (PRT) on serum rats following high-fat diet plus sucrose solution. Methods: A total 32 male Wistar were randomly divided into (HFDS) and standard (SD) groups. After 12 weeks, each group sedentary animals groups subjected to PRT program (3 days/week, for weeks). Flexor hallucis longus (FHL) gastrocnemius muscle weights, epididymal retroperitoneal fat glucose, insulin, myonectin, homeostasis model assessment insulin (HOMA-IR) measured this study. Results: results revealed HFDS increased weight gain, weight, HOMA-IR weights levels. Eight FHL weight. Conclusions: suggest may be an efficient intervention enhance levels, which associated improvement body composition.